Protein profile

KP13_05241

putative D-methionine transport system permease protein metI

Genome: KpKP13

Gene: AHE44648.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPQ4
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Amino acids 219
Annotations 4
Features 31
PDB binders 0
Druggability 0.871

Overview

Basic information about this protein and its source genome.

Accession
KP13_05241
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44648.1
Status
annotated
Amino acids
219
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0048473 The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.594
DEG E-value
1.17e-37
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.871
Structure A0A0H3GPQ4
Pocket Pocket 5
P2Rank 0.065
Structure A0A0H3GPQ4
Pocket Pocket 1
ColabFold model
FPocket 0.875 · Pocket 11
P2Rank 0.092 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 359 / 4744 genomes with a hit
Normalized 0.076

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0048473 The process in which D-methionine is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
147 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 217 Gene3D G3DSA:1.10.3720.10 -
4 217 InterPro IPR035906 MetI-like superfamily
19 201 CDD cd06261 TM_PBP2
19 201 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
118 136 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
55 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
209 219 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
42 52 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
151 173 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 206 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
14 206 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
6 218 FunFam G3DSA:1.10.3720.10:FF:000002 D-methionine ABC transporter permease MetI
44 217 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
44 217 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
189 208 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
185 207 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
107 117 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
136 146 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
53 77 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
118 135 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
78 82 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
83 105 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
169 188 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
2 217 PANTHER PTHR30450 ABC TRANSPORTER PERMEASE
7 201 SUPERFAMILY SSF161098 MetI-like
7 201 InterPro IPR035906 MetI-like superfamily
20 41 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 106 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPQ4
AlphaFold — — full sequence — Viewing
ColabFold KP13_05241
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.871

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.03 0.006