Protein profile

KP13_05276

Multiple antibiotic resistance protein marA

Genome: KpKP13

Gene: marA AHE44683.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN41
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Amino acids 125
Annotations 4
Features 16
PDB binders 0
Druggability 0.132

Overview

Basic information about this protein and its source genome.

Accession
KP13_05276
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
marA AHE44683.1
Status
annotated
Amino acids
125
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
92.742
DEG E-value
5.26e-85
Localization
Cytoplasmic
ColabFold pLDDT
92.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.132
Structure A0A0H3GN41
Pocket Pocket 1
P2Rank 0.085
Structure A0A0H3GN41
Pocket Pocket 1
ColabFold model
FPocket 0.358 · Pocket 1
P2Rank 0.06 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 92 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 63 Gene3D G3DSA:1.10.10.60 -
33 109 Pfam PF12833 Helix-turn-helix domain
33 109 InterPro IPR018060 DNA binding HTH domain, AraC-type
11 60 SUPERFAMILY SSF46689 Homeodomain-like
11 60 InterPro IPR009057 Homeobox-like domain superfamily
8 60 FunFam G3DSA:1.10.10.60:FF:000013 DNA-binding transcriptional activator MarA
13 111 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
13 111 InterPro IPR018060 DNA binding HTH domain, AraC-type
63 105 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
63 105 InterPro IPR018062 HTH domain AraC-type, conserved site
64 125 Gene3D G3DSA:1.10.10.60 -
63 110 SUPERFAMILY SSF46689 Homeodomain-like
63 110 InterPro IPR009057 Homeobox-like domain superfamily
2 119 PANTHER PTHR47504 RIGHT ORIGIN-BINDING PROTEIN
26 109 SMART SM00342 aracneu4
26 109 InterPro IPR018060 DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN41
AlphaFold — — full sequence — Viewing
ColabFold KP13_05276
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.96 0.041