Protein profile

KP13_05279

putative MFS-type transporter

Genome: KpKP13

Gene: AHE44686.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSM7
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Amino acids 404
Annotations 4
Features 49
PDB binders 0
Druggability 0.744

Overview

Basic information about this protein and its source genome.

Accession
KP13_05279
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44686.1
Status
annotated
Amino acids
404
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
71.429
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.744
Structure A0A0H3GSM7
Pocket Pocket 22
P2Rank 0.987
Structure A0A0H3GSM7
Pocket Pocket 1
ColabFold model
FPocket 0.32 · Pocket 8
P2Rank 0.983 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

49 records
Show feature table
Start End DB Term Name
81 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
330 340 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
341 363 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 30 Phobius SIGNAL_PEPTIDE Signal peptide region
388 404 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
271 281 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
128 138 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
368 387 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
305 329 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
50 72 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
213 239 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
282 299 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
50 72 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 162 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
341 363 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 348 Pfam PF07690 Major Facilitator Superfamily
19 348 InterPro IPR011701 Major facilitator superfamily
73 80 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
306 328 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
251 270 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
282 301 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 394 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
14 394 InterPro IPR020846 Major facilitator superfamily domain
6 388 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
6 388 InterPro IPR036259 MFS transporter superfamily
166 188 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
100 104 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
105 127 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
300 304 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
14 25 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
364 368 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
168 188 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
189 212 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
81 99 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 396 PANTHER PTHR23535 SUGAR EFFLUX TRANSPORTER A-RELATED
26 30 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
26 384 CDD cd17329 MFS_MdtH_MDR_like
251 270 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
163 167 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
139 162 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
219 241 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 388 SUPERFAMILY SSF103473 MFS general substrate transporter
12 388 InterPro IPR036259 MFS transporter superfamily
369 387 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
105 127 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
240 250 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSM7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05279
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
22 0.744
8 0.584
26 0.36

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 44.28 0.971
2 9.2 0.493
3 2.27 0.057
4 1.57 0.024
5 1.26 0.013