Protein profile

KP13_05284

putative high-affinity branched-chain amino acid ABC transporter membrane protein

Genome: KpKP13

Gene: AHE44691.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSM2
Export view
Amino acids 524
Annotations 5
Features 37
PDB binders 0
Druggability 0.776

Overview

Basic information about this protein and its source genome.

Accession
KP13_05284
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44691.1
Status
annotated
Amino acids
524
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.776
Structure A0A0H3GSM2
Pocket Pocket 1
P2Rank 0.333
Structure A0A0H3GSM2
Pocket Pocket 1
ColabFold model
FPocket 0.759 · Pocket 24
P2Rank 0.237 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 84 / 4744 genomes with a hit
Normalized 0.018

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

37 records
Show feature table
Start End DB Term Name
492 509 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
489 508 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
18 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
291 311 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
324 346 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
228 522 PANTHER PTHR11795 BRANCHED-CHAIN AMINO ACID TRANSPORT SYSTEM PERMEASE PROTEIN LIVH
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
9 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
393 458 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
114 220 SUPERFAMILY SSF48371 ARM repeat
114 220 InterPro IPR016024 Armadillo-type fold
251 516 CDD cd06582 TM_PBP1_LivH_like
509 524 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
346 374 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
266 285 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
312 322 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
323 345 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
228 250 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
461 483 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
232 507 Pfam PF02653 Branched-chain amino acid transport system / permease component
232 507 InterPro IPR001851 ABC transporter, permease
232 259 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
370 392 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
230 521 NCBIfam TIGR03409 urea ABC transporter permease subunit UrtB
230 521 InterPro IPR017779 ABC transporter, urea permease protein UrtB, bacterial-type
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
424 446 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
257 279 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
289 311 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
484 488 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
260 265 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
459 483 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 231 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
375 392 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
286 290 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSM2
AlphaFold — — full sequence — Viewing
ColabFold KP13_05284
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.776
2 0.269

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.74 0.343
2 5.85 0.286
3 5.61 0.27
4 2.61 0.075
5 0.73 0.002