Protein profile

KP13_05286

5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase

Genome: KpKP13

Gene: AHE44693.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN30
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Amino acids 367
Annotations 4
Features 9
PDB binders 0
Druggability 0.716

Overview

Basic information about this protein and its source genome.

Accession
KP13_05286
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44693.1
Status
annotated
Amino acids
367
Structure source
AlphaFold + ColabFold
GO
GO:0008270 Binding to a zinc ion (Zn). GO:0003871 Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. GO:0009086 OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.716
Structure A0A0H3GN30
Pocket Pocket 2
P2Rank 0.735
Structure A0A0H3GN30
Pocket Pocket 1
ColabFold model
FPocket 0.857 · Pocket 1
P2Rank 0.635 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 234 / 4744 genomes with a hit
Normalized 0.049

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0003871 Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
  • GO:0009086 OBSOLETE. The chemical reactions and pathways resulting in the de novo formation of L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
2 367 PANTHER PTHR43844 METHIONINE SYNTHASE
2 367 Gene3D G3DSA:3.20.20.210 -
2 367 InterPro IPR038071 UROD/MetE-like superfamily
10 367 SUPERFAMILY SSF51726 UROD/MetE-like
10 367 InterPro IPR038071 UROD/MetE-like superfamily
12 345 Pfam PF01717 Cobalamin-independent synthase, Catalytic domain
12 345 InterPro IPR002629 Cobalamin-independent methionine synthase MetE, C-terminal/archaeal
9 359 CDD cd03311 CIMS_C_terminal_like
9 359 InterPro IPR002629 Cobalamin-independent methionine synthase MetE, C-terminal/archaeal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN30
AlphaFold — — full sequence — Viewing
ColabFold KP13_05286
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.716
7 0.449
13 0.346

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.71 0.696
2 2.4 0.064
3 1.41 0.018