Protein profile

KP13_05295

Lactose permease

Genome: KpKP13

Gene: lacY AHE44702.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPL5
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Amino acids 423
Annotations 4
Features 68
PDB binders 0
Druggability 0.697

Overview

Basic information about this protein and its source genome.

Accession
KP13_05295
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
lacY AHE44702.1
Status
annotated
Amino acids
423
Structure source
AlphaFold + ColabFold
GO
GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
61.68
DEG E-value
1.51e-174
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.46

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.697
Structure A0A0H3GPL5
Pocket Pocket 27
P2Rank 0.967
Structure A0A0H3GPL5
Pocket Pocket 1
ColabFold model
FPocket 0.644 · Pocket 20
P2Rank 0.967 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 56 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008643 The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005351 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in).
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

68 records
Show feature table
Start End DB Term Name
311 333 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
229 246 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
35 53 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
388 407 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
287 297 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
388 410 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
229 246 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 85 ProSitePatterns PS00896 LacY family proton/sugar symporters signature 1.
71 85 InterPro IPR018457 LacY/RafB permease family, conserved site
377 387 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
170 174 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
356 376 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
298 317 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
194 228 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
408 423 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
12 212 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
12 212 InterPro IPR036259 MFS transporter superfamily
152 171 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
268 290 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
106 110 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
11 408 SUPERFAMILY SSF103473 MFS general substrate transporter
11 408 InterPro IPR036259 MFS transporter superfamily
175 193 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
323 344 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
52 74 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
137 147 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
54 72 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 411 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
15 411 InterPro IPR020846 Major facilitator superfamily domain
266 286 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
213 419 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
213 419 InterPro IPR036259 MFS transporter superfamily
9 411 Pfam PF01306 LacY proton/sugar symporter
9 411 InterPro IPR000576 LacY/RafB permease family
12 411 PANTHER PTHR23522 BLL5896 PROTEIN
73 83 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
247 265 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
110 132 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 15 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
353 375 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
29 407 CDD cd06172 MFS_LacY
14 407 NCBIfam TIGR00882 oligosaccharide MFS transporter
14 407 InterPro IPR000576 LacY/RafB permease family
111 136 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
16 34 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 105 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
318 322 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
148 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
345 355 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
84 105 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
267 288 PRINTS PR00174 LacY proton/sugar symporter family signature
267 288 InterPro IPR000576 LacY/RafB permease family
110 132 PRINTS PR00174 LacY proton/sugar symporter family signature
110 132 InterPro IPR000576 LacY/RafB permease family
221 249 PRINTS PR00174 LacY proton/sugar symporter family signature
221 249 InterPro IPR000576 LacY/RafB permease family
291 317 PRINTS PR00174 LacY proton/sugar symporter family signature
291 317 InterPro IPR000576 LacY/RafB permease family
152 170 PRINTS PR00174 LacY proton/sugar symporter family signature
152 170 InterPro IPR000576 LacY/RafB permease family
322 341 PRINTS PR00174 LacY proton/sugar symporter family signature
322 341 InterPro IPR000576 LacY/RafB permease family
75 104 PRINTS PR00174 LacY proton/sugar symporter family signature
75 104 InterPro IPR000576 LacY/RafB permease family
353 373 PRINTS PR00174 LacY proton/sugar symporter family signature
353 373 InterPro IPR000576 LacY/RafB permease family
175 194 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPL5
AlphaFold — — full sequence — Viewing
ColabFold KP13_05295
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
27 0.697
7 0.336

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 37.23 0.957
2 2.68 0.079
3 2.0 0.043
4 1.95 0.041
5 1.85 0.036