Protein profile

KP13_31848

putative RecF protein

Genome: KpKP13

Gene: AHE44703.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSL0
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Amino acids 381
Annotations 4
Features 16
PDB binders 0
Druggability 0.331

Overview

Basic information about this protein and its source genome.

Accession
KP13_31848
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44703.1
Status
annotated
Amino acids
381
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.331
Structure A0A0H3GSL0
Pocket Pocket 4
P2Rank 0.411
Structure A0A0H3GSL0
Pocket Pocket 1
ColabFold model
FPocket 0.365 · Pocket 1
P2Rank 0.249 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 31 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0000731 Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.
  • GO:0006302 The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
20 74 PANTHER PTHR32182 DNA REPLICATION AND REPAIR PROTEIN RECF
20 378 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
20 378 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
18 115 Gene3D G3DSA:3.40.50.300 -
18 115 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
17 381 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
225 380 Gene3D G3DSA:3.40.50.300 -
225 380 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
42 355 Pfam PF13304 AAA domain, putative AbiEii toxin, Type IV TA system
42 355 InterPro IPR003959 ATPase, AAA-type, core
19 381 PIRSF PIRSF029347 RecF
19 381 InterPro IPR014555 RecF-like
11 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSL0
AlphaFold — — full sequence — Viewing
ColabFold KP13_31848
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.331
2 0.28

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.8 0.213
2 1.66 0.028
3 1.51 0.022