Protein profile

KP13_01127

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE44706.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GX62
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Amino acids 253
Annotations 2
Features 23
PDB binders 0
Druggability 0.973

Overview

Basic information about this protein and its source genome.

Accession
KP13_01127
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44706.1
Status
annotated
Amino acids
253
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.973
Structure A0A0H3GX62
Pocket Pocket 1
P2Rank 0.32
Structure A0A0H3GX62
Pocket Pocket 1
ColabFold model
FPocket 0.344 · Pocket 6
P2Rank 0.346 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 43 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
75 232 Pfam PF00455 DeoR C terminal sensor domain
75 232 InterPro IPR014036 DeoR C-terminal sensor domain
38 56 PRINTS PR00037 LacR bacterial regulatory protein HTH signature
38 56 InterPro IPR001034 DeoR-type HTH domain
24 38 PRINTS PR00037 LacR bacterial regulatory protein HTH signature
24 38 InterPro IPR001034 DeoR-type HTH domain
5 69 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
5 69 InterPro IPR036390 Winged helix DNA-binding domain superfamily
6 40 ProSitePatterns PS00894 DeoR-type HTH domain signature.
6 40 InterPro IPR018356 Transcription regulator, HTH DeoR-type, conserved site
3 58 ProSiteProfiles PS51000 DeoR-type HTH domain profile.
3 58 InterPro IPR001034 DeoR-type HTH domain
73 228 Gene3D G3DSA:3.40.50.1360 -
6 60 Pfam PF08220 DeoR-like helix-turn-helix domain
6 60 InterPro IPR001034 DeoR-type HTH domain
5 70 Gene3D G3DSA:1.10.10.10 -
5 70 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
1 250 PANTHER PTHR30363 HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED
73 233 SMART SM01134 DeoRC_2
6 58 SMART SM00420 deor2
6 58 InterPro IPR001034 DeoR-type HTH domain
75 233 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
75 233 InterPro IPR037171 NagB/RpiA transferase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX62
AlphaFold — — full sequence — Viewing
ColabFold KP13_01127
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.973

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.61 0.135
2 1.52 0.022