Protein profile

KP13_01130

Putative aldolase class 2 protein

Genome: KpKP13

Gene: AHE44709.1 Structure source: Experimental + ColabFold UniProt Q0QC76
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Amino acids 206
Annotations 5
Features 10
PDB binders 2
Druggability 0.345

Overview

Basic information about this protein and its source genome.

Accession
KP13_01130
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44709.1
Status
annotated
Amino acids
206
Structure source
Experimental + ColabFold
EC
4.1.1.104
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016832 Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. GO:0046872 Binding to a metal ion. GO:0019323 The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
28.276
Human E-value
3.74e-06
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
98.25

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.345
Structure 6VOQ
Pocket Pocket 1
P2Rank
Structure 6VOQ
Pocket No pockets
ColabFold model
FPocket 0.427 · Pocket 2
P2Rank 0.046 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0016832 Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
  • GO:0046872 Binding to a metal ion.
  • GO:0019323 The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
8 185 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain
8 185 InterPro IPR001303 Class II aldolase/adducin N-terminal
2 205 PANTHER PTHR22789 FUCULOSE PHOSPHATE ALDOLASE
8 187 SMART SM01007 Aldolase_II_2
8 187 InterPro IPR001303 Class II aldolase/adducin N-terminal
1 206 Gene3D G3DSA:3.40.225.10 -
1 206 InterPro IPR036409 Class II aldolase/adducin N-terminal domain superfamily
2 206 FunFam G3DSA:3.40.225.10:FF:000008 Sugar aldolase
1 205 SUPERFAMILY SSF53639 AraD/HMP-PK domain-like
1 205 InterPro IPR036409 Class II aldolase/adducin N-terminal domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6VOQ
X-ray 2.49 Å A
100.0% 1-206
PDBe RCSB PDBj File
Viewing
ColabFold KP13_01130
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.345

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
13P
1E47
P0AB87 170.1 Da LogP -1.34 TPSA 104.1 ✓ Ro5 ✓ Clean C(C(=O)COP(=O)(O)O)O
PGH
4FUA
P0AB87 171.0 Da LogP -1.40 TPSA 116.1 ✓ Ro5 ✓ Clean C(C(=O)NO)OP(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.