Protein profile

KP13_01131

putative epimerase/isomerase

Genome: KpKP13

Gene: AHE44710.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GN12
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Amino acids 260
Annotations 2
Features 9
PDB binders 0
Druggability 0.481

Overview

Basic information about this protein and its source genome.

Accession
KP13_01131
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44710.1
Status
annotated
Amino acids
260
Structure source
AlphaFold + ColabFold
GO
GO:0008903 Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. GO:0046487 The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
48.571
Human E-value
1.47e-64
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
57.752
DEG E-value
9.309999999999999e-114
Localization
Cytoplasmic
ColabFold pLDDT
97.8

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.481
Structure A0A0H3GN12
Pocket Pocket 4
P2Rank 0.552
Structure A0A0H3GN12
Pocket Pocket 1
ColabFold model
FPocket 0.219 · Pocket 6
P2Rank 0.467 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 49 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008903 Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate.
  • GO:0046487 The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
21 253 Pfam PF01261 Xylose isomerase-like TIM barrel
21 253 InterPro IPR013022 Xylose isomerase-like, TIM barrel domain
1 259 SUPERFAMILY SSF51658 Xylose isomerase-like
1 259 InterPro IPR036237 Xylose isomerase-like superfamily
1 260 PIRSF PIRSF006241 HyI
1 260 InterPro IPR026040 Hydroxypyruvate isomerase-like
1 258 FunFam G3DSA:3.20.20.150:FF:000007 Hydroxypyruvate isomerase
1 260 Gene3D G3DSA:3.20.20.150 -
3 257 PANTHER PTHR43489 ISOMERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GN12
AlphaFold — — full sequence — Viewing
ColabFold KP13_01131
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.481

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.4 0.448
2 0.6 0.0