Protein profile

KP13_01135

LuxR transcriptional regulator

Genome: KpKP13

Gene: AHE44714.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSK1
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Amino acids 203
Annotations 2
Features 18
PDB binders 0
Druggability 0.656

Overview

Basic information about this protein and its source genome.

Accession
KP13_01135
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44714.1
Status
annotated
Amino acids
203
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.656
Structure A0A0H3GSK1
Pocket Pocket 7
P2Rank 0.075
Structure A0A0H3GSK1
Pocket Pocket 1
ColabFold model
FPocket 0.485 · Pocket 15
P2Rank 0.045 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 4 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
152 192 Pfam PF00196 Bacterial regulatory proteins, luxR family
152 192 InterPro IPR000792 Transcription regulator LuxR, C-terminal
144 193 CDD cd06170 LuxR_C_like
144 193 InterPro IPR000792 Transcription regulator LuxR, C-terminal
136 201 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
136 201 InterPro IPR000792 Transcription regulator LuxR, C-terminal
140 197 SMART SM00421 luxrmega5
140 197 InterPro IPR000792 Transcription regulator LuxR, C-terminal
129 195 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
129 195 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
103 201 Gene3D G3DSA:1.10.10.10 -
103 201 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
143 157 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
143 157 InterPro IPR000792 Transcription regulator LuxR, C-terminal
157 173 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
157 173 InterPro IPR000792 Transcription regulator LuxR, C-terminal
173 185 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
173 185 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSK1
AlphaFold — — full sequence — Viewing
ColabFold KP13_01135
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.656
1 0.254

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.94 0.04
2 1.18 0.01