Protein profile

KP13_32394

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE44726.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EP80
Export view
Amino acids 283
Annotations 3
Features 24
PDB binders 0
Druggability 0.317

Overview

Basic information about this protein and its source genome.

Accession
KP13_32394
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44726.1
Status
annotated
Amino acids
283
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
80.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.317
Structure A0A6A8EP80
Pocket Pocket 17
P2Rank 0.207
Structure A0A6A8EP80
Pocket Pocket 1
ColabFold model
FPocket 0.539 · Pocket 17
P2Rank 0.247 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 8 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
200 282 SMART SM00342 aracneu4
200 282 InterPro IPR018060 DNA binding HTH domain, AraC-type
236 282 SUPERFAMILY SSF46689 Homeodomain-like
236 282 InterPro IPR009057 Homeobox-like domain superfamily
181 283 FunFam G3DSA:1.10.10.60:FF:000132 AraC family transcriptional regulator
58 137 Pfam PF02311 AraC-like ligand binding domain
58 137 InterPro IPR003313 AraC-type arabinose-binding/dimerisation domain
42 119 Gene3D G3DSA:2.60.120.10 Jelly Rolls
42 119 InterPro IPR014710 RmlC-like jelly roll fold
180 283 Gene3D G3DSA:1.10.10.60 -
187 283 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
187 283 InterPro IPR018060 DNA binding HTH domain, AraC-type
237 278 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
237 278 InterPro IPR018062 HTH domain AraC-type, conserved site
251 266 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
251 266 InterPro IPR020449 Transcription regulator HTH, AraC- type
266 282 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
266 282 InterPro IPR020449 Transcription regulator HTH, AraC- type
206 281 Pfam PF12833 Helix-turn-helix domain
206 281 InterPro IPR018060 DNA binding HTH domain, AraC-type
28 211 SUPERFAMILY SSF51182 RmlC-like cupins
28 211 InterPro IPR011051 RmlC-like cupin domain superfamily
57 140 CDD cd06124 cupin_NimR-like_N
48 282 PANTHER PTHR11019 HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EP80
AlphaFold — — full sequence — Viewing
ColabFold KP13_32394
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.317
4 0.228

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.94 0.094
2 1.57 0.024
3 1.09 0.007
4 1.08 0.007