Protein profile

KP13_01149

Universal stress protein G

Genome: KpKP13

Gene: AHE44731.1 uspG Structure source: AlphaFold + ColabFold UniProt A0A0H3GPI2
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Amino acids 143
Annotations 0
Features 15
PDB binders 0
Druggability 0.456

Overview

Basic information about this protein and its source genome.

Accession
KP13_01149
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44731.1 uspG
Status
annotated
Amino acids
143
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.0
DEG E-value
2.4700000000000002e-29
Localization
Cytoplasmic
ColabFold pLDDT
88.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.456
Structure A0A0H3GPI2
Pocket Pocket 1
P2Rank 0.217
Structure A0A0H3GPI2
Pocket Pocket 1
ColabFold model
FPocket 0.618 · Pocket 14
P2Rank 0.322 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
1 143 Pfam PF00582 Universal stress protein family
1 143 InterPro IPR006016 UspA
4 142 CDD cd00293 USP_Like
1 143 PIRSF PIRSF006276 UspA
1 143 InterPro IPR006015 Universal stress protein A family
1 143 Gene3D G3DSA:3.40.50.620 HUPs
1 143 InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
1 143 SUPERFAMILY SSF52402 Adenine nucleotide alpha hydrolases-like
63 143 PANTHER PTHR46268 STRESS RESPONSE PROTEIN NHAX
2 20 PRINTS PR01438 Universal stress protein signature
2 20 InterPro IPR006015 Universal stress protein A family
104 116 PRINTS PR01438 Universal stress protein signature
104 116 InterPro IPR006015 Universal stress protein A family
121 143 PRINTS PR01438 Universal stress protein signature
121 143 InterPro IPR006015 Universal stress protein A family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPI2
AlphaFold — — full sequence — Viewing
ColabFold KP13_01149
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.456
8 0.41