Protein profile

KP13_01161

Twin-arginine leader-binding protein dmsD

Genome: KpKP13

Gene: AHE44741.1 dmsD Structure source: AlphaFold + ColabFold UniProt A0A0H3GT23
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Amino acids 203
Annotations 1
Features 15
PDB binders 0
Druggability 0.346

Overview

Basic information about this protein and its source genome.

Accession
KP13_01161
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44741.1 dmsD
Status
annotated
Amino acids
203
Structure source
AlphaFold + ColabFold
GO
GO:0005048 Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.346
Structure A0A0H3GT23
Pocket Pocket 3
P2Rank 0.156
Structure A0A0H3GT23
Pocket Pocket 1
ColabFold model
FPocket 0.808 · Pocket 1
P2Rank 0.126 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 71 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005048 Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
56 162 Pfam PF02613 Nitrate reductase delta subunit
56 162 InterPro IPR020945 DMSO/Nitrate reductase chaperone
1 31 Phobius SIGNAL_PEPTIDE Signal peptide region
8 202 SUPERFAMILY SSF89155 TorD-like
8 202 InterPro IPR036411 TorD-like superfamily
6 203 Hamap MF_00940 Tat proofreading chaperone DmsD [dmsD].
6 203 InterPro IPR028611 Tat proofreading chaperone DmsD
23 31 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
32 203 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 203 PIRSF PIRSF004690 DmsD
3 203 InterPro IPR026269 Tat proofreading chaperone DmsD-type
5 202 PANTHER PTHR34227 CHAPERONE PROTEIN YCDY
10 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 203 Gene3D G3DSA:1.10.3480.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT23
AlphaFold — — full sequence — Viewing
ColabFold KP13_01161
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.346

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.44 0.066