Protein profile

KP13_31743

putative serine protease

Genome: KpKP13

Gene: AHE44752.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMY0
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Amino acids 270
Annotations 4
Features 30
PDB binders 0
Druggability 0.212

Overview

Basic information about this protein and its source genome.

Accession
KP13_31743
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44752.1
Status
annotated
Amino acids
270
Structure source
AlphaFold + ColabFold
EC
3.4.21.-
GO
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008236 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.212
Structure A0A0H3GMY0
Pocket Pocket 1
P2Rank 0.791
Structure A0A0H3GMY0
Pocket Pocket 1
ColabFold model
FPocket 0.285 · Pocket 1
P2Rank 0.716 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0008236 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
  • GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
51 162 Gene3D G3DSA:2.40.10.10 -
51 162 InterPro IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
36 239 Gene3D G3DSA:2.40.10.10 -
36 239 InterPro IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
5 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
26 264 SUPERFAMILY SSF50494 Trypsin-like serine proteases
26 264 InterPro IPR009003 Peptidase S1, PA clan
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
22 270 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
214 225 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site.
214 225 InterPro IPR033116 Serine proteases, trypsin family, serine active site
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
30 252 PANTHER PTHR15462 SERINE PROTEASE
16 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
209 225 PRINTS PR00839 V8 serine protease family signature
209 225 InterPro IPR008256 Peptidase S1B
41 58 PRINTS PR00839 V8 serine protease family signature
41 58 InterPro IPR008256 Peptidase S1B
175 188 PRINTS PR00839 V8 serine protease family signature
175 188 InterPro IPR008256 Peptidase S1B
66 83 PRINTS PR00839 V8 serine protease family signature
66 83 InterPro IPR008256 Peptidase S1B
229 241 PRINTS PR00839 V8 serine protease family signature
229 241 InterPro IPR008256 Peptidase S1B
77 82 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site.
77 82 InterPro IPR018114 Serine proteases, trypsin family, histidine active site
46 241 Pfam PF00089 Trypsin
46 241 InterPro IPR001254 Serine proteases, trypsin domain
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMY0
AlphaFold — — full sequence — Viewing
ColabFold KP13_31743
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.212

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.89 0.584