Protein profile

KP13_01175

2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase

Genome: KpKP13

Gene: mdcB AHE44758.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GX15
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Amino acids 280
Annotations 5
Features 11
PDB binders 0
Druggability 0.828

Overview

Basic information about this protein and its source genome.

Accession
KP13_01175
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mdcB AHE44758.1
Status
annotated
Amino acids
280
Structure source
AlphaFold + ColabFold
EC
2.4.2.52
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0046917 Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. GO:0051191 The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.94

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.828
Structure A0A0H3GX15
Pocket Pocket 3
P2Rank 0.965
Structure A0A0H3GX15
Pocket Pocket 1
ColabFold model
FPocket 0.865 · Pocket 3
P2Rank 0.95 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 62 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
  • GO:0046917 Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine.
  • GO:0051191 The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
14 278 PANTHER PTHR30201 TRIPHOSPHORIBOSYL-DEPHOSPHO-COA SYNTHASE
14 278 InterPro IPR002736 Triphosphoribosyl-dephospho-CoA protein
1 23 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 280 Hamap MF_01883 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase [mdcB].
1 280 InterPro IPR017555 Triphosphoribosyl-dephospho-CoA synthase
17 275 Pfam PF01874 ATP:dephospho-CoA triphosphoribosyl transferase
17 275 InterPro IPR002736 Triphosphoribosyl-dephospho-CoA protein
41 141 Gene3D G3DSA:1.10.4200.10 -
147 280 Gene3D G3DSA:1.10.4200.10 -
16 278 NCBIfam TIGR03132 triphosphoribosyl-dephospho-CoA synthase MdcB
16 278 InterPro IPR017555 Triphosphoribosyl-dephospho-CoA synthase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX15
AlphaFold — — full sequence — Viewing
ColabFold KP13_01175
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.828
1 0.732

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.97 0.923
2 7.17 0.373