Protein profile

KP13_01178

Malonate decarboxylase subunit gamma

Genome: KpKP13

Gene: mdcE AHE44761.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GT06
Export view
Amino acids 266
Annotations 1
Features 6
PDB binders 0
Druggability 0.679

Overview

Basic information about this protein and its source genome.

Accession
KP13_01178
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
mdcE AHE44761.1
Status
annotated
Amino acids
266
Structure source
AlphaFold + ColabFold
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.679
Structure A0A0H3GT06
Pocket Pocket 1
P2Rank 0.099
Structure A0A0H3GT06
Pocket Pocket 1
ColabFold model
FPocket 0.732 · Pocket 2
P2Rank 0.032 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 74 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
11 266 Pfam PF06833 Malonate decarboxylase gamma subunit (MdcE)
10 266 NCBIfam TIGR03134 biotin-independent malonate decarboxylase subunit gamma
10 266 InterPro IPR009648 Biotin-dependent malonate decarboxylase, gamma subunit
24 225 SUPERFAMILY SSF52096 ClpP/crotonase
24 225 InterPro IPR029045 ClpP/crotonase-like domain superfamily
14 263 Gene3D G3DSA:3.90.226.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GT06
AlphaFold — — full sequence — Viewing
ColabFold KP13_01178
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.679

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.26 0.056
2 1.58 0.024