Protein profile

KP13_05045

4-carboxymuconolactone decarboxylase

Genome: KpKP13

Gene: pcaC AHE44783.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWW4
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Amino acids 129
Annotations 3
Features 9
PDB binders 0
Druggability 0.498

Overview

Basic information about this protein and its source genome.

Accession
KP13_05045
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pcaC AHE44783.1
Status
annotated
Amino acids
129
Structure source
AlphaFold + ColabFold
EC
4.1.1.44
GO
GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH. GO:0047575 Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.29

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.498
Structure A0A0H3GWW4
Pocket Pocket 3
P2Rank 0.405
Structure A0A0H3GWW4
Pocket Pocket 1
ColabFold model
FPocket 0.611 · Pocket 3
P2Rank 0.328 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 39 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
  • GO:0047575 Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
36 118 Pfam PF02627 Carboxymuconolactone decarboxylase family
36 118 InterPro IPR003779 Carboxymuconolactone decarboxylase-like
4 128 Gene3D G3DSA:1.20.1290.10 -
4 128 InterPro IPR029032 AhpD-like
4 124 NCBIfam TIGR02425 4-carboxymuconolactone decarboxylase
4 124 InterPro IPR012788 4-carboxymuconolactone decarboxylase
5 123 SUPERFAMILY SSF69118 AhpD-like
5 123 InterPro IPR029032 AhpD-like
3 123 PANTHER PTHR33570 4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWW4
AlphaFold — — full sequence — Viewing
ColabFold KP13_05045
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.498
1 0.188
4 0.089
2 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.83 0.405
2 1.7 0.024