Protein profile

KP13_05038

hypothetical protein

Genome: KpKP13

Gene: AHE44787.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSD7
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Amino acids 187
Annotations 1
Features 13
PDB binders 0
Druggability 0.378

Overview

Basic information about this protein and its source genome.

Accession
KP13_05038
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44787.1
Status
annotated
Amino acids
187
Structure source
AlphaFold + ColabFold
GO
GO:0004520 Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
80.749
DEG E-value
1.68e-117
Localization
Cytoplasmic
ColabFold pLDDT
88.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.378
Structure A0A0H3GSD7
Pocket Pocket 3
P2Rank 0.012
Structure A0A0H3GSD7
Pocket Pocket 1
ColabFold model
FPocket 0.392 · Pocket 6
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 74 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004520 Catalysis of the cleavage of ester linkages within deoxyribonucleic acid by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
88 169 ProSiteProfiles PS50828 Smr domain profile.
88 169 InterPro IPR002625 Smr domain
88 169 SUPERFAMILY SSF160443 SMR domain-like
88 169 InterPro IPR036063 Smr domain superfamily
2 175 PANTHER PTHR35562 DNA ENDONUCLEASE SMRA-RELATED
85 169 SMART SM00463 SMR_2
85 169 InterPro IPR002625 Smr domain
39 175 Gene3D G3DSA:3.30.1370.110 -
39 175 InterPro IPR036063 Smr domain superfamily
94 169 Pfam PF01713 Smr domain
94 169 InterPro IPR002625 Smr domain
4 185 NCBIfam NF033154 DNA endonuclease SmrA
4 185 InterPro IPR047688 DNA endonuclease SmrA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSD7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05038
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.378
5 0.302
11 0.266

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.13 0.008