Protein profile

KP13_05017

DNA replication terminus site-binding protein

Genome: KpKP13

Gene: tus AHE44808.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMP2
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Amino acids 310
Annotations 3
Features 12
PDB binders 0
Druggability 0.646

Overview

Basic information about this protein and its source genome.

Accession
KP13_05017
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
tus AHE44808.1
Status
annotated
Amino acids
310
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006274 The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
70.227
DEG E-value
2.96e-162
Localization
Cytoplasmic
ColabFold pLDDT
93.36

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.646
Structure A0A0H3GMP2
Pocket Pocket 1
P2Rank 0.026
Structure A0A0H3GMP2
Pocket Pocket 1
ColabFold model
FPocket 0.711 · Pocket 2
P2Rank 0.053 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 89 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0006274 The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
10 307 NCBIfam TIGR02648 DNA replication terminus site-binding protein
10 307 InterPro IPR008865 DNA replication terminus site-binding protein
9 306 Pfam PF05472 DNA replication terminus site-binding protein (Ter protein)
9 306 InterPro IPR008865 DNA replication terminus site-binding protein
174 306 Gene3D G3DSA:3.30.54.10 -
7 27 Coils Coil Coil
1 309 Hamap MF_00483 DNA replication terminus site-binding protein [tus].
1 309 InterPro IPR008865 DNA replication terminus site-binding protein
13 281 Gene3D G3DSA:3.50.14.10 Replication terminator Tus, domain 1 superfamily/Replication terminator Tus
13 281 InterPro IPR036381 Replication terminator Tus, domain 1
5 307 SUPERFAMILY SSF56596 Replication terminator protein (Tus)
5 307 InterPro IPR036384 Replication terminator Tus superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMP2
AlphaFold — — full sequence — Viewing
ColabFold KP13_05017
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.024
3 0.0
17 0.0
27 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.74 0.026
2 1.73 0.025
3 1.68 0.024