Protein profile

KP13_04999

hypothetical protein

Genome: KpKP13

Gene: AHE44826.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMM8
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Amino acids 266
Annotations 1
Features 13
PDB binders 0
Druggability 0.305

Overview

Basic information about this protein and its source genome.

Accession
KP13_04999
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44826.1
Status
annotated
Amino acids
266
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.305
Structure A0A0H3GMM8
Pocket Pocket 7
P2Rank 0.685
Structure A0A0H3GMM8
Pocket Pocket 1
ColabFold model
FPocket 0.341 · Pocket 8
P2Rank 0.707 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 60 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
26 181 Gene3D G3DSA:3.40.50.620 HUPs
26 181 InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
8 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 266 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
8 253 PANTHER PTHR30336 INNER MEMBRANE PROTEIN, PROBABLE PERMEASE
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
39 172 Pfam PF02698 DUF218 domain
39 172 InterPro IPR003848 Domain of unknown function DUF218
38 171 CDD cd06259 YdcF-like
38 171 InterPro IPR003848 Domain of unknown function DUF218
8 250 Gene3D G3DSA:1.10.3620.10 YdcF like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMM8
AlphaFold — — full sequence — Viewing
ColabFold KP13_04999
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.305

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.46 0.26
2 3.05 0.101