Protein profile

KP13_04992

Arginine N-succinyltransferase

Genome: KpKP13

Gene: AHE44833.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWQ3
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Amino acids 341
Annotations 3
Features 10
PDB binders 0
Druggability 0.265

Overview

Basic information about this protein and its source genome.

Accession
KP13_04992
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44833.1
Status
annotated
Amino acids
341
Structure source
AlphaFold + ColabFold
EC
2.3.1.109
GO
GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine. GO:0008791 Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
52.478
DEG E-value
1.45e-122
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.265
Structure A0A0H3GWQ3
Pocket Pocket 6
P2Rank 0.963
Structure A0A0H3GWQ3
Pocket Pocket 1
ColabFold model
FPocket 0.268 · Pocket 14
P2Rank 0.966 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0006527 The chemical reactions and pathways resulting in the breakdown of L-arginine.
  • GO:0008791 Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 332 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
1 332 InterPro IPR016181 Acyl-CoA N-acyltransferase
1 332 PANTHER PTHR30420 N-SUCCINYLARGININE DIHYDROLASE
3 331 NCBIfam TIGR03243 arginine and ornithine succinyltransferase subunits
3 331 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG
280 332 Gene3D G3DSA:2.40.40.20 -
1 330 Pfam PF04958 Arginine N-succinyltransferase beta subunit
1 330 InterPro IPR007041 Arginine N-succinyltransferase AstA/AruG
3 332 NCBIfam TIGR03244 arginine N-succinyltransferase
3 332 InterPro IPR017650 Arginine N-succinyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWQ3
AlphaFold — — full sequence — Viewing
ColabFold KP13_04992
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.265

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.46 0.899
2 7.9 0.42
3 2.9 0.092