Protein profile

KP13_04985

RND efflux system, membrane fusion protein

Genome: KpKP13

Gene: AHE44842.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GML2
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Amino acids 361
Annotations 1
Features 17
PDB binders 0
Druggability 0.663

Overview

Basic information about this protein and its source genome.

Accession
KP13_04985
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44842.1
Status
annotated
Amino acids
361
Structure source
AlphaFold + ColabFold
GO
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
53.774
DEG E-value
5.92e-113
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.19

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.663
Structure A0A0H3GML2
Pocket Pocket 11
P2Rank
Structure A0A0H3GML2
Pocket No pockets
ColabFold model
FPocket 0.488 · Pocket 3
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 59 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
41 354 Pfam PF00529 Cation efflux system protein CusB domain 1
41 354 InterPro IPR043602 Cation efflux system protein CusB, domain 1
41 361 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
241 360 Gene3D G3DSA:2.40.30.170 -
20 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
61 94 Gene3D G3DSA:2.40.50.100 -
1 359 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
61 303 Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion
61 303 InterPro IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain
62 141 SUPERFAMILY SSF111369 HlyD-like secretion proteins
122 156 Coils Coil Coil
202 222 Coils Coil Coil
95 122 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
124 194 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
201 354 SUPERFAMILY SSF111369 HlyD-like secretion proteins

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GML2
AlphaFold — — full sequence — Viewing
ColabFold KP13_04985
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.663
2 0.304