Protein profile

KP13_04980

hypothetical protein

Genome: KpKP13

Gene: AHE44847.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMK7
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Amino acids 84
Annotations 2
Features 8
PDB binders 0
Druggability 0.242

Overview

Basic information about this protein and its source genome.

Accession
KP13_04980
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44847.1
Status
annotated
Amino acids
84
Structure source
AlphaFold + ColabFold
GO
GO:0016846 Catalysis of the elimination of hydrogen sulfide or substituted H2S. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
42.857
Human E-value
4.27e-09
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.242
Structure A0A0H3GMK7
Pocket Pocket 1
P2Rank 0.468
Structure A0A0H3GMK7
Pocket Pocket 1
ColabFold model
FPocket 0.576 · Pocket 2
P2Rank 0.51 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016846 Catalysis of the elimination of hydrogen sulfide or substituted H2S.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 70 ProSiteProfiles PS51891 CENP-V/GFA domain profile.
1 70 InterPro IPR006913 CENP-V/GFA domain
1 71 Gene3D G3DSA:2.170.150.70 -
2 64 PANTHER PTHR28620 CENTROMERE PROTEIN V
2 71 SUPERFAMILY SSF51316 Mss4-like
2 71 InterPro IPR011057 Mss4-like superfamily
4 53 Pfam PF04828 Glutathione-dependent formaldehyde-activating enzyme
4 53 InterPro IPR006913 CENP-V/GFA domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMK7
AlphaFold — — full sequence — Viewing
ColabFold KP13_04980
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.242

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.4 0.256