Protein profile

KP13_04978

Phenylacetic acid degradation operon negative regulatory protein paaX

Genome: KpKP13

Gene: paaX AHE44849.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GP18
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Amino acids 311
Annotations 1
Features 12
PDB binders 0
Druggability 0.501

Overview

Basic information about this protein and its source genome.

Accession
KP13_04978
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
paaX AHE44849.1
Status
annotated
Amino acids
311
Structure source
AlphaFold + ColabFold
GO
GO:0006351 The synthesis of an RNA transcript from a DNA template.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.279
DEG E-value
0.0
Localization
Unknown
ColabFold pLDDT
93.78

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.501
Structure A0A0H3GP18
Pocket Pocket 2
P2Rank 0.476
Structure A0A0H3GP18
Pocket Pocket 1
ColabFold model
FPocket 0.597 · Pocket 8
P2Rank 0.295 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 43 / 4744 genomes with a hit
Normalized 0.009

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0006351 The synthesis of an RNA transcript from a DNA template.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
4 309 PIRSF PIRSF020623 PaaX
4 309 InterPro IPR011965 Phenylacetic acid degradation operon negative regulatory protein PaaX
21 102 Gene3D G3DSA:1.10.10.10 -
21 102 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
4 288 PANTHER PTHR30319 PHENYLACETIC ACID REGULATOR-RELATED TRANSCRIPTIONAL REPRESSOR
212 286 Gene3D G3DSA:1.20.58.1460 -
186 284 Pfam PF08223 PaaX-like protein C-terminal domain
186 284 InterPro IPR013225 PaaX-like, C-terminal
24 306 NCBIfam TIGR02277 phenylacetic acid degradation operon negative regulatory protein PaaX
24 306 InterPro IPR011965 Phenylacetic acid degradation operon negative regulatory protein PaaX
22 90 Pfam PF07848 PaaX-like protein
22 90 InterPro IPR012906 PaaX-like, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GP18
AlphaFold — — full sequence — Viewing
ColabFold KP13_04978
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.451
7 0.451
4 0.006
31 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.29 0.476
2 3.42 0.098
3 2.73 0.066
4 2.07 0.038
5 1.17 0.009