Protein profile

KP13_04969

Phenylacetic acid degradation protein paaC

Genome: KpKP13

Gene: paaC AHE44858.1 Structure source: Experimental + AlphaFold + ColabFold UniProt A6T8I2
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Amino acids 251
Annotations 1
Features 12
PDB binders 0
Druggability 0.364

Overview

Basic information about this protein and its source genome.

Accession
KP13_04969
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
paaC AHE44858.1
Status
annotated
Amino acids
251
Structure source
Experimental + AlphaFold + ColabFold
GO
GO:0010124 The chemical reactions and pathways resulting in the breakdown of phenylacetate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
74.899
DEG E-value
3.09e-139
Localization
Unknown
ColabFold pLDDT
97.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.364
Structure A6T8I2
Pocket Pocket 4
P2Rank 0.203
Structure A6T8I2
Pocket Pocket 1
ColabFold model
FPocket 0.544 · Pocket 1
P2Rank 0.133 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 57 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0010124 The chemical reactions and pathways resulting in the breakdown of phenylacetate.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 251 PIRSF PIRSF037834 PaaC
1 251 InterPro IPR011882 1,2-phenylacetyl-CoA epoxidase, subunit C
5 251 Pfam PF05138 Phenylacetic acid catabolic protein
5 251 InterPro IPR007814 1,2-phenylacetyl-CoA epoxidase, subunit A/C
1 251 FunFam G3DSA:1.20.1260.10:FF:000012 1,2-phenylacetyl-CoA epoxidase, subunit C
11 251 PANTHER PTHR30458 PHENYLACETIC ACID DEGRADATION PROTEIN PAA
14 251 NCBIfam TIGR02158 phenylacetate-CoA oxygenase subunit PaaC
14 251 InterPro IPR011882 1,2-phenylacetyl-CoA epoxidase, subunit C
1 251 Gene3D G3DSA:1.20.1260.10 -
1 251 InterPro IPR012347 Ferritin-like
7 245 SUPERFAMILY SSF47240 Ferritin-like
7 245 InterPro IPR009078 Ferritin-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4IIT
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
AlphaFold AF_A6T8I2
AlphaFold — — full sequence — Loaded
ColabFold KP13_04969
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer