Protein profile

KP13_05593

Transcriptional activator feaR

Genome: KpKP13

Gene: feaR AHE44867.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSM1
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Amino acids 314
Annotations 3
Features 16
PDB binders 0
Druggability 0.615

Overview

Basic information about this protein and its source genome.

Accession
KP13_05593
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
feaR AHE44867.1
Status
annotated
Amino acids
314
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
85.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.615
Structure A0A0H3GSM1
Pocket Pocket 1
P2Rank 0.429
Structure A0A0H3GSM1
Pocket Pocket 1
ColabFold model
FPocket 0.512 · Pocket 1
P2Rank 0.468 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 37 / 4744 genomes with a hit
Normalized 0.008

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
232 312 Pfam PF12833 Helix-turn-helix domain
232 312 InterPro IPR018060 DNA binding HTH domain, AraC-type
226 310 SMART SM00342 aracneu4
226 310 InterPro IPR018060 DNA binding HTH domain, AraC-type
205 314 Gene3D G3DSA:1.10.10.60 -
279 294 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
279 294 InterPro IPR020449 Transcription regulator HTH, AraC- type
294 310 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
294 310 InterPro IPR020449 Transcription regulator HTH, AraC- type
69 314 PANTHER PTHR46796 HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
212 312 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
212 312 InterPro IPR018060 DNA binding HTH domain, AraC-type
261 313 SUPERFAMILY SSF46689 Homeodomain-like
261 313 InterPro IPR009057 Homeobox-like domain superfamily
28 198 Pfam PF14525 AraC-binding-like domain
28 198 InterPro IPR035418 Transcription regulator HTH, AraC- type, ligand binding domain-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSM1
AlphaFold — — full sequence — Viewing
ColabFold KP13_05593
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.009
25 0.002
6 0.0
14 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.34 0.429
2 2.93 0.076
3 1.87 0.031
4 1.44 0.016