Protein profile

KP13_05587

hypothetical protein

Genome: KpKP13

Gene: AHE44873.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNY1

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Amino acids 148

Annotations 0

Features 13

PDB binders 0

Druggability 0.323

Overview

Basic information about this protein and its source genome.

Accession: KP13_05587
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE44873.1
Status: annotated
Amino acids: 148
Structure source: AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 63.699
DEG E-value: 5.14e-63
Localization: Unknown
ColabFold pLDDT: 88.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.323

Structure A0A0H3GNY1

Pocket Pocket 5

P2Rank

Structure A0A0H3GNY1

Pocket No pockets

ColabFold model

FPocket 0.665 · Pocket 2

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 59 / 4744 genomes with a hit

Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records

Show feature table

Start	End	DB	Term	Name
18	22	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	22	SignalP_EUK	SignalP-noTM	SignalP-noTM
1	5	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	28	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
23	148	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3	145	PANTHER	PTHR35535	HEAT SHOCK PROTEIN HSLJ
6	17	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
36	143	Gene3D	G3DSA:2.40.128.270	-
36	143	InterPro	IPR038670	HslJ-like superfamily
1	22	Phobius	SIGNAL_PEPTIDE	Signal peptide region
30	140	Pfam	PF03724	META domain
30	140	InterPro	IPR005184	Domain of unknown function DUF306, Meta/HslJ
1	19	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GNY1	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_05587	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.323

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.665