Protein profile

KP13_04358

putative HTH-type transcriptional regulator

Genome: KpKP13

Gene: AHE44910.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSH8
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Amino acids 209
Annotations 1
Features 13
PDB binders 0
Druggability 0.822

Overview

Basic information about this protein and its source genome.

Accession
KP13_04358
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44910.1
Status
annotated
Amino acids
209
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
55.897
DEG E-value
4.0900000000000003e-72
Localization
Cytoplasmic
ColabFold pLDDT
90.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.822
Structure A0A0H3GSH8
Pocket Pocket 1
P2Rank 0.801
Structure A0A0H3GSH8
Pocket Pocket 1
ColabFold model
FPocket 0.805 · Pocket 1
P2Rank 0.793 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
45 75 ProSitePatterns PS01081 TetR-type HTH domain signature.
45 75 InterPro IPR023772 DNA-binding HTH domain, TetR-type, conserved site
34 77 Pfam PF00440 Bacterial regulatory proteins, tetR family
34 77 InterPro IPR001647 DNA-binding HTH domain, TetR-type
27 87 ProSiteProfiles PS50977 TetR-type HTH domain profile.
27 87 InterPro IPR001647 DNA-binding HTH domain, TetR-type
100 200 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
100 200 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
23 203 PANTHER PTHR47506 TRANSCRIPTIONAL REGULATORY PROTEIN
20 101 SUPERFAMILY SSF46689 Homeodomain-like
20 101 InterPro IPR009057 Homeobox-like domain superfamily
19 86 Gene3D G3DSA:1.10.10.60 -
89 205 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSH8
AlphaFold — — full sequence — Viewing
ColabFold KP13_04358
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.822

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.88 0.737
2 2.04 0.045