Protein profile

KP13_04352

IcmF-related domain-containing protein

Genome: KpKP13

Gene: AHE44917.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS02
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Amino acids 1141
Annotations 0
Features 15
PDB binders 0
Druggability 0.975

Overview

Basic information about this protein and its source genome.

Accession
KP13_04352
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44917.1
Status
annotated
Amino acids
1141
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
81.5

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.975
Structure A0A0H3GS02
Pocket Pocket 26
P2Rank 0.355
Structure A0A0H3GS02
Pocket Pocket 1
ColabFold model
FPocket 0.999 · Pocket 103
P2Rank 0.066 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 27 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
14 1116 PANTHER PTHR36153 INNER MEMBRANE PROTEIN-RELATED
416 733 Pfam PF06761 Intracellular multiplication and human macrophage-killing
416 733 InterPro IPR009612 IcmF-related
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
992 1096 Pfam PF06744 Type VI secretion protein IcmF C2-like domain
992 1096 InterPro IPR010623 Type VI secretion system IcmF, C-terminal
369 390 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
391 1141 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
368 390 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
78 368 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
55 77 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
37 55 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 36 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
56 77 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS02
AlphaFold — — full sequence — Viewing
ColabFold KP13_04352
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
26 0.975

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.57 0.267
2 2.33 0.06
3 1.18 0.01