Protein profile

KP13_04343

Type VI secretion system Vgr family protein

Genome: KpKP13

Gene: AHE44925.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRZ3
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Amino acids 789
Annotations 0
Features 19
PDB binders 0
Druggability 0.932

Overview

Basic information about this protein and its source genome.

Accession
KP13_04343
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44925.1
Status
annotated
Amino acids
789
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
54.522
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.932
Structure A0A0H3GRZ3
Pocket Pocket 2
P2Rank 0.357
Structure A0A0H3GRZ3
Pocket Pocket 1
ColabFold model
FPocket 0.767 · Pocket 35
P2Rank 0.219 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 27 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
11 166 Gene3D G3DSA:2.30.110.50 -
292 368 Gene3D G3DSA:2.30.110.50 -
79 192 PANTHER PTHR32305 -
14 511 NCBIfam TIGR03361 type VI secretion system tip protein TssI/VgrG N-terminal domain
14 511 InterPro IPR017847 Type VI secretion system, RhsGE-associated Vgr family subset
200 381 SUPERFAMILY SSF69279 Phage tail proteins
386 470 Gene3D G3DSA:2.40.50.230 -
386 470 InterPro IPR037026 Vgr protein, OB-fold domain superfamily
404 471 Pfam PF04717 Type VI secretion system/phage-baseplate injector OB domain
404 471 InterPro IPR006531 Gp5/Type VI secretion system Vgr protein, OB-fold domain
23 514 NCBIfam TIGR01646 type VI secretion system tip protein VgrG
23 514 InterPro IPR006533 Type VI secretion system, RhsGE-associated Vgr protein
380 470 SUPERFAMILY SSF69255 gp5 N-terminal domain-like
610 755 Pfam PF10106 Uncharacterized protein conserved in bacteria (DUF2345)
610 755 InterPro IPR018769 Type VI secretion system spike protein VgrG2, domain of unknown function DUF2345
490 585 Pfam PF13296 Putative type VI secretion system Rhs element Vgr
490 585 InterPro IPR028244 Putative type VI secretion system, Rhs element associated Vgr domain
31 351 Pfam PF05954 Phage tail baseplate hub (GPD)
12 189 SUPERFAMILY SSF69279 Phage tail proteins

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRZ3
AlphaFold — — full sequence — Viewing
ColabFold KP13_04343
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.932
1 0.448
59 0.234
11 0.213

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.24 0.244
2 2.94 0.095
3 2.55 0.072
4 2.11 0.048
5 1.54 0.023