Protein profile

KP13_04341

Hcp family type VI secretion system protein

Genome: KpKP13

Gene: AHE44927.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GMC3
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Amino acids 163
Annotations 0
Features 9
PDB binders 0
Druggability 0.2

Overview

Basic information about this protein and its source genome.

Accession
KP13_04341
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44927.1
Status
annotated
Amino acids
163
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Extracellular
ColabFold pLDDT
94.76

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.2
Structure A0A0H3GMC3
Pocket Pocket 1
P2Rank 0.168
Structure A0A0H3GMC3
Pocket Pocket 1
ColabFold model
FPocket 0.074 · Pocket 2
P2Rank 0.15 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 160 NCBIfam TIGR03344 type VI secretion system tube protein TssD/Hcp
1 160 InterPro IPR008514 Type VI secretion system effector Hcp
2 160 SUPERFAMILY SSF141452 Hcp1-like
2 160 InterPro IPR036624 Hcp1-like superfamily
1 154 PANTHER PTHR34319 MAJOR EXPORTED PROTEIN
1 163 Gene3D G3DSA:2.30.110.20 -
1 163 InterPro IPR036624 Hcp1-like superfamily
6 146 Pfam PF05638 Type VI secretion system effector, Hcp
6 146 InterPro IPR008514 Type VI secretion system effector Hcp

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GMC3
AlphaFold — — full sequence — Viewing
ColabFold KP13_04341
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.46 0.126