Protein profile

KP13_31922

EvpB family type VI secretion protein

Genome: KpKP13

Gene: AHE44931.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSE9
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Amino acids 516
Annotations 0
Features 8
PDB binders 0
Druggability 0.217

Overview

Basic information about this protein and its source genome.

Accession
KP13_31922
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44931.1
Status
annotated
Amino acids
516
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
45.035
DEG E-value
3.43e-131
Localization
Cytoplasmic
ColabFold pLDDT
84.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.217
Structure A0A0H3GSE9
Pocket Pocket 5
P2Rank 0.858
Structure A0A0H3GSE9
Pocket Pocket 1
ColabFold model
FPocket 0.593 · Pocket 49
P2Rank 0.808 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 67 / 4744 genomes with a hit
Normalized 0.014

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
91 391 Pfam PF05943 EvpB/VC_A0108, tail sheath N-terminal domain
91 391 InterPro IPR044031 TssC1, N-terminal
18 515 PANTHER PTHR35565 CYTOPLASMIC PROTEIN-RELATED
18 515 InterPro IPR010269 Type VI secretion system TssC-like
401 511 Pfam PF18945 EvpB/VC_A0108, tail sheath gpW/gp25-like domain
401 511 InterPro IPR044032 TssC1, C-terminal
54 512 NCBIfam TIGR03355 type VI secretion system contractile sheath large subunit
54 512 InterPro IPR010269 Type VI secretion system TssC-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSE9
AlphaFold — — full sequence — Viewing
ColabFold KP13_31922
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.217

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.97 0.812
2 6.75 0.344
3 4.14 0.168
4 1.85 0.036
5 1.57 0.024