Protein profile

KP13_05453

hypothetical protein

Genome: KpKP13

Gene: AHE44957.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRR4
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Amino acids 353
Annotations 0
Features 20
PDB binders 0
Druggability 0.602

Overview

Basic information about this protein and its source genome.

Accession
KP13_05453
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44957.1
Status
annotated
Amino acids
353
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
83.853
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
74.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.602
Structure A0A0H3GRR4
Pocket Pocket 44
P2Rank 0.673
Structure A0A0H3GRR4
Pocket Pocket 1
ColabFold model
FPocket 0.861 · Pocket 29
P2Rank 0.181 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 108 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
256 275 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
99 120 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
11 336 NCBIfam TIGR01620 TIGR01620 family protein
11 336 InterPro IPR006507 Uncharacterised protein family UPF0283
1 353 PANTHER PTHR39342 UPF0283 MEMBRANE PROTEIN YCJF
1 353 InterPro IPR006507 Uncharacterised protein family UPF0283
70 89 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
276 353 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
214 236 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
184 341 Pfam PF05128 Domain of unknown function (DUF697)
184 341 InterPro IPR021147 Protein of unknown function DUF697
70 87 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 347 Hamap MF_01085 UPF0283 membrane protein YcjF [ycjF].
4 347 InterPro IPR006507 Uncharacterised protein family UPF0283
1 69 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
88 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
121 213 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
99 121 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
211 233 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
237 255 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRR4
AlphaFold — — full sequence — Viewing
ColabFold KP13_05453
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
44 0.602
36 0.001
43 0.001
19 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.47 0.673
2 1.6 0.021
3 1.27 0.011
4 1.21 0.009