Protein profile

KP13_05449

Phage shock protein B

Genome: KpKP13

Gene: pspB AHE44961.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GNG7
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Amino acids 74
Annotations 2
Features 11
PDB binders 0
Druggability 0.199

Overview

Basic information about this protein and its source genome.

Accession
KP13_05449
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pspB AHE44961.1
Status
annotated
Amino acids
74
Structure source
AlphaFold + ColabFold
GO
GO:0009271 A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.13

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.199
Structure A0A0H3GNG7
Pocket Pocket 2
P2Rank
Structure A0A0H3GNG7
Pocket No pockets
ColabFold model
FPocket 0.419 · Pocket 5
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 110 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0009271 A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
20 74 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
3 73 Pfam PF06667 Phage shock protein B
3 73 InterPro IPR009554 Phage shock protein B
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 74 NCBIfam TIGR02976 envelope stress response membrane protein PspB
1 74 InterPro IPR009554 Phage shock protein B
43 63 Coils Coil Coil
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
16 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNG7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05449
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer