Protein profile

KP13_05439

Peptide transport system permease protein sapB

Genome: KpKP13

Gene: sapB AHE44970.1 Structure source: AlphaFold + ColabFold UniProt A0A2X3H2X0
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Amino acids 321
Annotations 4
Features 29
PDB binders 0
Druggability 0.394

Overview

Basic information about this protein and its source genome.

Accession
KP13_05439
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sapB AHE44970.1
Status
annotated
Amino acids
321
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
88.162
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.394
Structure A0A2X3H2X0
Pocket Pocket 29
P2Rank 0.293
Structure A0A2X3H2X0
Pocket Pocket 1
ColabFold model
FPocket 0.928 · Pocket 1
P2Rank 0.553 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 115 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0071916 Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
1 37 Phobius SIGNAL_PEPTIDE Signal peptide region
114 136 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
270 280 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
92 311 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
92 311 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
142 248 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 317 PANTHER PTHR43163 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB-RELATED
286 308 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
74 302 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
74 302 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
303 321 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
281 302 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
74 297 CDD cd06261 TM_PBP2
74 297 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
9 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
103 113 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
66 307 Gene3D G3DSA:1.10.3720.10 -
66 307 InterPro IPR035906 MetI-like superfamily
114 141 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
38 81 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
20 37 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
69 300 SUPERFAMILY SSF161098 MetI-like
69 300 InterPro IPR035906 MetI-like superfamily
251 273 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
80 102 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
82 102 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
249 269 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A2X3H2X0
AlphaFold — — full sequence — Viewing
ColabFold KP13_05439
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
29 0.394
6 0.381

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.57 0.267
2 4.3 0.178
3 3.93 0.155
4 1.53 0.023
5 1.31 0.014