Protein profile

KP13_05438

Peptide transport system permease protein sapC

Genome: KpKP13

Gene: sapC AHE44971.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRQ6
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Amino acids 296
Annotations 2
Features 33
PDB binders 0
Druggability 0.891

Overview

Basic information about this protein and its source genome.

Accession
KP13_05438
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sapC AHE44971.1
Status
annotated
Amino acids
296
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
90.541
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.891
Structure A0A0H3GRQ6
Pocket Pocket 1
P2Rank 0.615
Structure A0A0H3GRQ6
Pocket Pocket 1
ColabFold model
FPocket 0.894 · Pocket 2
P2Rank 0.487 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 118 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
99 284 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
99 284 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
261 283 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
198 217 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
258 280 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
85 292 Gene3D G3DSA:1.10.3720.10 -
85 292 InterPro IPR035906 MetI-like superfamily
224 243 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
16 66 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
16 66 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain
284 296 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
242 260 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
170 188 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
98 268 CDD cd06261 TM_PBP2
98 268 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
210 220 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
31 54 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
55 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
134 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
99 123 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
124 143 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
85 292 FunFam G3DSA:1.10.3720.10:FF:000019 Antimicrobial peptide ABC transporter permease SapC
90 276 SUPERFAMILY SSF161098 MetI-like
90 276 InterPro IPR035906 MetI-like superfamily
30 52 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
144 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
113 292 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
113 292 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
1 30 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 291 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
99 121 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
189 209 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
221 241 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRQ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_05438
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.891

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.17 0.599
2 4.03 0.161
3 2.53 0.071
4 1.47 0.02
5 1.1 0.008