Protein profile

KP13_05428

Osmotically-inducible lipoprotein B

Genome: KpKP13

Gene: AHE44981.1 osmB Structure source: AlphaFold + ColabFold UniProt A0A0H3GM06
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Amino acids 82
Annotations 1
Features 12
PDB binders 0
Druggability 0.824

Overview

Basic information about this protein and its source genome.

Accession
KP13_05428
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44981.1 osmB
Status
annotated
Amino acids
82
Structure source
AlphaFold + ColabFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
86.111
DEG E-value
4.32e-21
Localization
CytoplasmicMembrane
ColabFold pLDDT
62.68

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.824
Structure A0A0H3GM06
Pocket Pocket 7
P2Rank
Structure A0A0H3GM06
Pocket No pockets
ColabFold model
FPocket 0.795 · Pocket 2
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 107 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
21 38 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 82 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 18 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 34 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
53 75 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
43 81 Pfam PF05433 Glycine zipper 2TM domain
43 81 InterPro IPR008816 Glycine zipper 2TM domain
28 32 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
19 27 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 33 SignalP_GRAM_NEGATIVE SignalP-TM SignalP-TM
1 40 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 32 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GM06
AlphaFold — — full sequence — Viewing
ColabFold KP13_05428
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.824
6 0.6