Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_05427
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE44982.1
Status: annotated
Amino acids: 108
Structure source: AlphaFold + ColabFold

GO

GO:0003743 Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0006413 The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. GO:0001731 The joining of the small ribosomal subunit, ternary complex, and mRNA. GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. GO:0002188 A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 92.593
DEG E-value: 1.93e-66
Localization: Unknown
ColabFold pLDDT: 71.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.127

Structure A0A0H3GW60

Pocket Pocket 1

P2Rank

Structure A0A0H3GW60

Pocket No pockets

ColabFold model

FPocket 0.182 · Pocket 3

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 147 / 4744 genomes with a hit

Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0003743 Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
GO:0006413 The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
GO:0003729 Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
GO:0001731 The joining of the small ribosomal subunit, ternary complex, and mRNA.
GO:0006417 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
GO:0002188 A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records

Show feature table

Start	End	DB	Term	Name
1	108	PIRSF	PIRSF037511	Transl_init_SUI1_prok
1	108	InterPro	IPR005872	Archaeal/bacterial translation initiation factor SUI1
8	108	NCBIfam	TIGR01158	stress response translation initiation inhibitor YciH
8	108	InterPro	IPR005872	Archaeal/bacterial translation initiation factor SUI1
26	99	PANTHER	PTHR12789	DENSITY-REGULATED PROTEIN HOMOLOG
1	27	MobiDBLite	mobidb-lite	consensus disorder prediction
32	101	Pfam	PF01253	Translation initiation factor SUI1
32	101	InterPro	IPR001950	SUI1 domain
28	108	Gene3D	G3DSA:3.30.780.10	-
5	104	SUPERFAMILY	SSF55159	eIF1-like
5	104	InterPro	IPR036877	SUI1 domain superfamily
31	106	CDD	cd11567	YciH_like
31	106	InterPro	IPR005872	Archaeal/bacterial translation initiation factor SUI1
34	100	ProSiteProfiles	PS50296	Translation initiation factor SUI1 family profile.
34	100	InterPro	IPR001950	SUI1 domain
28	108	FunFam	G3DSA:3.30.780.10:FF:000002	Stress response translation initiation inhibitor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GW60 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GW60	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_05427	ColabFold	—	—	full sequence	—	Loaded

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
NO2	5ZCY	P58193	46.0 Da LogP 0.25 TPSA 52.5	✓ Ro5	✓ Clean	`N(=O)[O-]`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

KP13_05427