Protein profile

KP13_05425

tetratricopeptide repeat-containing protein

Genome: KpKP13

Gene: AHE44983.1 Structure source: AlphaFold + ColabFold UniProt A0A377ZIJ6
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Amino acids 388
Annotations 5
Features 32
PDB binders 0
Druggability 0.328

Overview

Basic information about this protein and its source genome.

Accession
KP13_05425
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44983.1
Status
annotated
Amino acids
388
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0008653 The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0009898 The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. GO:0005506 Binding to an iron (Fe) ion. GO:0046890 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
86.016
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.328
Structure A0A377ZIJ6
Pocket Pocket 3
P2Rank 0.321
Structure A0A377ZIJ6
Pocket Pocket 1
ColabFold model
FPocket 0.507 · Pocket 8
P2Rank 0.298 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 116 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005515 Binding to a protein.
  • GO:0008653 The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
  • GO:0009898 The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0046890 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
12 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
213 246 ProSiteProfiles PS50005 TPR repeat profile.
213 246 InterPro IPR019734 Tetratricopeptide repeat
4 386 Hamap MF_00994 Lipopolysaccharide assembly protein B [lapB].
4 386 InterPro IPR030865 Lipopolysaccharide assembly protein B
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
17 388 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
39 318 PANTHER PTHR45586 TPR REPEAT-CONTAINING PROTEIN PA4667
190 244 Pfam PF14559 Tetratricopeptide repeat
1 16 SignalP_EUK SignalP-noTM SignalP-noTM
38 182 FunFam G3DSA:1.25.40.10:FF:000033 Lipopolysaccharide assembly protein B
354 381 Pfam PF18073 Rubredoxin metal binding domain
354 381 InterPro IPR041166 LapB, rubredoxin metal binding domain
4 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region
38 132 SUPERFAMILY SSF48452 TPR-like
38 132 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
175 344 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
175 344 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
281 314 SMART SM00028 tpr_5
281 314 InterPro IPR019734 Tetratricopeptide repeat
179 212 SMART SM00028 tpr_5
179 212 InterPro IPR019734 Tetratricopeptide repeat
213 246 SMART SM00028 tpr_5
106 139 SMART SM00028 tpr_5
106 139 InterPro IPR019734 Tetratricopeptide repeat
68 101 SMART SM00028 tpr_5
68 101 InterPro IPR019734 Tetratricopeptide repeat
39 174 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
39 174 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
108 278 SUPERFAMILY SSF48452 TPR-like
108 278 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A377ZIJ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_05425
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.328

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.6 0.134
2 1.52 0.022
3 1.36 0.016
4 1.31 0.014