Protein profile

KP13_05345

putative protease sohB

Genome: KpKP13

Gene: sohB AHE44992.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLY9
Export view
Amino acids 360
Annotations 4
Features 16
PDB binders 0
Druggability 0.659

Overview

Basic information about this protein and its source genome.

Accession
KP13_05345
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
sohB AHE44992.1
Status
annotated
Amino acids
360
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.003
DEG E-value
3.3e-117
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.659
Structure A0A0H3GLY9
Pocket Pocket 6
P2Rank 0.179
Structure A0A0H3GLY9
Pocket Pocket 1
ColabFold model
FPocket 0.097 · Pocket 33
P2Rank 0.188 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 148 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
  • GO:0004252 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
111 310 SUPERFAMILY SSF52096 ClpP/crotonase
111 310 InterPro IPR029045 ClpP/crotonase-like domain superfamily
1 21 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
22 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
172 320 Pfam PF01343 Peptidase family S49
172 320 InterPro IPR002142 Peptidase S49
45 360 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
116 312 CDD cd07023 S49_Sppa_N_C
116 312 InterPro IPR047272 Signal peptide peptidase A-like, C-terminal
109 322 Gene3D G3DSA:3.90.226.10 -
217 278 Gene3D G3DSA:6.20.330.10 -
81 104 MobiDBLite mobidb-lite consensus disorder prediction
14 169 Pfam PF08496 Peptidase family S49 N-terminal
14 169 InterPro IPR013703 Peptidase S49, N-terminal proteobacteria
16 360 PANTHER PTHR42987 PEPTIDASE S49

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLY9
AlphaFold — — full sequence — Viewing
ColabFold KP13_05345
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.659

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.27 0.114
2 2.29 0.058