Protein profile

KP13_05348

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Genome: KpKP13

Gene: AHE44995.1 btuR Structure source: AlphaFold + ColabFold UniProt A0A0H3GRN8
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Amino acids 196
Annotations 3
Features 17
PDB binders 0
Druggability 0.305

Overview

Basic information about this protein and its source genome.

Accession
KP13_05348
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44995.1 btuR
Status
annotated
Amino acids
196
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008817 Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin. GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.714
DEG E-value
2.03e-130
Localization
Cytoplasmic
ColabFold pLDDT
94.29

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.305
Structure A0A0H3GRN8
Pocket Pocket 4
P2Rank 0.355
Structure A0A0H3GRN8
Pocket Pocket 1
ColabFold model
FPocket 0.201 · Pocket 6
P2Rank 0.487 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 126 / 4744 genomes with a hit
Normalized 0.027

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0008817 Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin.
  • GO:0009236 The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 196 PIRSF PIRSF015617 Adenosyltransferase_CobA
1 196 InterPro IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR
28 196 CDD cd00561 CobA_ACA
28 196 InterPro IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR
3 21 Pfam PF12557 Cob(I)alamin adenosyltransferase N terminal
3 21 InterPro IPR025826 Cob(I)alamin adenosyltransferase N-terminal domain
7 196 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
7 196 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
7 27 Coils Coil Coil
6 196 FunFam G3DSA:3.40.50.300:FF:000937 Corrinoid adenosyltransferase
24 196 NCBIfam TIGR00708 cob(I)yrinic acid a,c-diamide adenosyltransferase
24 196 InterPro IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR
28 196 Pfam PF02572 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP
6 196 Gene3D G3DSA:3.40.50.300 -
6 196 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
2 196 PANTHER PTHR46638 CORRINOID ADENOSYLTRANSFERASE
2 196 InterPro IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/BtuR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRN8
AlphaFold — — full sequence — Viewing
ColabFold KP13_05348
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.305

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.02 0.099
2 1.59 0.025