Protein profile

KP13_05351

hypothetical protein

Genome: KpKP13

Gene: AHE44998.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW41
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Amino acids 302
Annotations 2
Features 40
PDB binders 0
Druggability 0.88

Overview

Basic information about this protein and its source genome.

Accession
KP13_05351
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE44998.1
Status
annotated
Amino acids
302
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.0

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.88
Structure A0A0H3GW41
Pocket Pocket 2
P2Rank 0.974
Structure A0A0H3GW41
Pocket Pocket 1
ColabFold model
FPocket 0.907 · Pocket 1
P2Rank 0.972 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 13 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records
Show feature table
Start End DB Term Name
190 295 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
95 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
9 22 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
93 115 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
38 139 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
141 145 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
217 236 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 88 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
123 140 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 40 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 288 PANTHER PTHR32322 INNER MEMBRANE TRANSPORTER
180 202 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
146 168 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
90 94 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
214 235 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
36 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
9 136 Pfam PF00892 EamA-like transporter family
9 136 InterPro IPR000620 EamA domain
149 289 Pfam PF00892 EamA-like transporter family
149 289 InterPro IPR000620 EamA domain
274 293 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 31 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
169 179 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
290 302 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
265 269 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
122 141 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
115 122 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
203 213 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
145 167 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
70 89 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
236 246 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
247 264 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 31 Phobius SIGNAL_PEPTIDE Signal peptide region
270 289 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
248 270 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
41 58 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
180 202 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
59 69 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW41
AlphaFold — — full sequence — Viewing
ColabFold KP13_05351
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.88
8 0.756

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 39.16 0.961
2 2.91 0.093
3 2.32 0.06
4 2.24 0.055
5 1.91 0.039