Protein profile

KP13_05353

Protein trpH

Genome: KpKP13

Gene: AHE45000.1 trpH Structure source: AlphaFold + ColabFold UniProt A0A0H3GRN3
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Amino acids 280
Annotations 1
Features 11
PDB binders 0
Druggability 0.313

Overview

Basic information about this protein and its source genome.

Accession
KP13_05353
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45000.1 trpH
Status
annotated
Amino acids
280
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
51.648
DEG E-value
6.439999999999999e-95
Localization
Cytoplasmic
ColabFold pLDDT
96.82

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.313
Structure A0A0H3GRN3
Pocket Pocket 10
P2Rank 0.913
Structure A0A0H3GRN3
Pocket Pocket 1
ColabFold model
FPocket 0.27 · Pocket 1
P2Rank 0.898 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 140 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
3 70 SMART SM00481 npolultra
3 70 InterPro IPR003141 Polymerase/histidinol phosphatase, N-terminal
4 158 Pfam PF02811 PHP domain
4 158 InterPro IPR004013 PHP domain
4 250 Gene3D G3DSA:3.20.20.140 -
98 169 Gene3D G3DSA:1.10.150.650 -
1 276 SUPERFAMILY SSF89550 PHP domain-like
1 276 InterPro IPR016195 Polymerase/histidinol phosphatase-like
98 169 FunFam G3DSA:1.10.150.650:FF:000001 PHP domain protein
3 250 CDD cd07438 PHP_HisPPase_AMP
1 261 PANTHER PTHR42924 EXONUCLEASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRN3
AlphaFold — — full sequence — Viewing
ColabFold KP13_05353
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.313
7 0.237

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.34 0.888
2 1.11 0.008