Protein profile

KP13_05360

putative hydroxypyruvate reductase

Genome: KpKP13

Gene: AHE45007.1 ttuD Structure source: AlphaFold + ColabFold UniProt A0A0H3GS22
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Amino acids 419
Annotations 2
Features 11
PDB binders 0
Druggability 0.477

Overview

Basic information about this protein and its source genome.

Accession
KP13_05360
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45007.1 ttuD
Status
annotated
Amino acids
419
Structure source
AlphaFold + ColabFold
GO
GO:0008887 Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
44.076
Human E-value
1.0099999999999999e-38
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.62

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.477
Structure A0A0H3GS22
Pocket Pocket 10
P2Rank 0.926
Structure A0A0H3GS22
Pocket Pocket 1
ColabFold model
FPocket 0.347 · Pocket 11
P2Rank 0.912 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 24 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008887 Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
306 412 Pfam PF05161 MOFRL family
306 412 InterPro IPR007835 MOFRL domain
238 419 Gene3D G3DSA:3.40.1480.10 MOFRL domain
238 419 InterPro IPR037035 Glycerate kinase-like, C-terminal domain superfamily
7 418 PANTHER PTHR12227 GLYCERATE KINASE
7 418 InterPro IPR039760 MOFRL domain-containing protein
26 237 Gene3D G3DSA:3.40.50.10180 -
26 237 InterPro IPR038614 Glycerate kinase, N-terminal domain superfamily
10 230 Pfam PF13660 Domain of unknown function (DUF4147)
10 230 InterPro IPR025286 MOFRL-associated domain
7 418 SUPERFAMILY SSF82544 GckA/TtuD-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS22
AlphaFold — — full sequence — Viewing
ColabFold KP13_05360
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.477

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.36 0.88
2 5.18 0.239
3 0.83 0.003