Protein profile

KP13_05364

MarR family transcriptional regulator

Genome: KpKP13

Gene: AHE45011.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRM7
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Amino acids 152
Annotations 2
Features 22
PDB binders 0
Druggability 0.737

Overview

Basic information about this protein and its source genome.

Accession
KP13_05364
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45011.1
Status
annotated
Amino acids
152
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.737
Structure A0A0H3GRM7
Pocket Pocket 8
P2Rank
Structure A0A0H3GRM7
Pocket No pockets
ColabFold model
FPocket 0.834 · Pocket 11
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
14 146 ProSiteProfiles PS50995 MarR-type HTH domain profile.
14 146 InterPro IPR000835 MarR-type HTH domain
46 97 Pfam PF12802 MarR family
46 97 InterPro IPR000835 MarR-type HTH domain
94 110 PRINTS PR00598 Bacterial regulatory protein MarR family signature
94 110 InterPro IPR000835 MarR-type HTH domain
58 74 PRINTS PR00598 Bacterial regulatory protein MarR family signature
58 74 InterPro IPR000835 MarR-type HTH domain
75 90 PRINTS PR00598 Bacterial regulatory protein MarR family signature
75 90 InterPro IPR000835 MarR-type HTH domain
124 144 PRINTS PR00598 Bacterial regulatory protein MarR family signature
124 144 InterPro IPR000835 MarR-type HTH domain
32 134 SMART SM00347 marrlong4
32 134 InterPro IPR000835 MarR-type HTH domain
6 151 Gene3D G3DSA:1.10.10.10 -
6 151 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
54 86 CDD cd00090 HTH_ARSR
54 86 InterPro IPR011991 ArsR-like helix-turn-helix domain
32 146 PANTHER PTHR33164 TRANSCRIPTIONAL REGULATOR, MARR FAMILY
32 146 InterPro IPR039422 Transcription regulators MarR/SlyA-like
32 149 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
32 149 InterPro IPR036390 Winged helix DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRM7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05364
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.737