Protein profile

KP13_05365

putative dehydrogenase

Genome: KpKP13

Gene: AHE45012.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS15
Export view
Amino acids 315
Annotations 1
Features 9
PDB binders 0
Druggability 0.788

Overview

Basic information about this protein and its source genome.

Accession
KP13_05365
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45012.1
Status
annotated
Amino acids
315
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
34.884
Human E-value
6.12e-15
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.788
Structure A0A0H3GS15
Pocket Pocket 4
P2Rank 0.691
Structure A0A0H3GS15
Pocket Pocket 1
ColabFold model
FPocket 0.788 · Pocket 11
P2Rank 0.725 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 289 PANTHER PTHR43677 SHORT-CHAIN DEHYDROGENASE/REDUCTASE
104 264 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
104 264 InterPro IPR036291 NAD(P)-binding domain superfamily
8 287 SMART SM00829 PKS_ER_names_mod
8 287 InterPro IPR020843 Polyketide synthase, enoylreductase domain
1 137 SUPERFAMILY SSF50129 GroES-like
1 137 InterPro IPR011032 GroES-like superfamily
17 302 Gene3D G3DSA:3.90.180.10 -
112 286 Gene3D G3DSA:3.40.50.720 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS15
AlphaFold — — full sequence — Viewing
ColabFold KP13_05365
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.788

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.88 0.583
2 9.09 0.486