Protein profile

KP13_05371

Outer membrane protein W

Genome: KpKP13

Gene: ompW AHE45017.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS09
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Amino acids 224
Annotations 3
Features 13
PDB binders 2
Druggability 0.998

Overview

Basic information about this protein and its source genome.

Accession
KP13_05371
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ompW AHE45017.1
Status
annotated
Amino acids
224
Structure source
AlphaFold + ColabFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
87.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.998
Structure A0A0H3GS09
Pocket Pocket 1
P2Rank 0.151
Structure A0A0H3GS09
Pocket Pocket 1
ColabFold model
FPocket 0.996 · Pocket 1
P2Rank 0.166 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 119 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
34 224 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35 224 SUPERFAMILY SSF56925 OMPA-like
35 224 InterPro IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel
27 33 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
16 26 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
35 224 Pfam PF03922 OmpW family
35 224 InterPro IPR005618 Outer membrane protein, OmpW
34 224 FunFam G3DSA:2.40.160.20:FF:000001 Outer membrane protein W
1 33 Phobius SIGNAL_PEPTIDE Signal peptide region
1 15 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
34 224 Gene3D G3DSA:2.40.160.20 -
13 224 PANTHER PTHR36920 -
13 224 InterPro IPR005618 Outer membrane protein, OmpW

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS09
AlphaFold — — full sequence — Viewing
ColabFold KP13_05371
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.998

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.2 0.375
2 1.96 0.041
3 1.05 0.006

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
C8E
2F1T
P0A915 306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO
LDA
2F1T
P0A915 229.4 Da LogP 4.48 TPSA 23.1 ✓ Ro5 ✓ Clean CCCCCCCCCCCC[N+](C)(C)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.