Protein profile

KP13_05374

putative intracellular septation protein

Genome: KpKP13

Gene: AHE45020.1 ispZ Structure source: AlphaFold + ColabFold UniProt A0A0H3GNA1
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Amino acids 179
Annotations 2
Features 24
PDB binders 0
Druggability 0.972

Overview

Basic information about this protein and its source genome.

Accession
KP13_05374
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE45020.1 ispZ
Status
annotated
Amino acids
179
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.62
DEG E-value
1.5e-121
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.972
Structure A0A0H3GNA1
Pocket Pocket 6
P2Rank 0.855
Structure A0A0H3GNA1
Pocket Pocket 1
ColabFold model
FPocket 0.964 · Pocket 5
P2Rank 0.506 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 122 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
1 178 PANTHER PTHR36917 INTRACELLULAR SEPTATION PROTEIN A-RELATED
1 178 InterPro IPR006008 Inner membrane-spanning protein YciB
1 175 Pfam PF04279 Intracellular septation protein A
1 175 InterPro IPR006008 Inner membrane-spanning protein YciB
40 50 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
151 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 177 NCBIfam TIGR00997 septation protein IspZ
1 177 InterPro IPR006008 Inner membrane-spanning protein YciB
51 68 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 176 Hamap MF_00189 Membrane-spanning protein YciB [yciB].
1 176 InterPro IPR006008 Inner membrane-spanning protein YciB
69 73 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
78 95 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
74 96 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 150 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
51 68 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 39 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
119 141 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
97 116 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
151 170 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
171 179 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
117 139 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GNA1
AlphaFold — — full sequence — Viewing
ColabFold KP13_05374
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.972

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.87 0.764
2 3.52 0.129
3 1.76 0.032
4 1.01 0.006