Protein profile

KP13_05391

Osmotically-inducible lipoprotein E

Genome: KpKP13

Gene: osmE AHE45036.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLT9
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Amino acids 112
Annotations 1
Features 13
PDB binders 0
Druggability 0.355

Overview

Basic information about this protein and its source genome.

Accession
KP13_05391
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
osmE AHE45036.1
Status
annotated
Amino acids
112
Structure source
AlphaFold + ColabFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
84.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.355
Structure A0A0H3GLT9
Pocket Pocket 3
P2Rank
Structure A0A0H3GLT9
Pocket No pockets
ColabFold model
FPocket 0.618 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 79 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
24 112 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
32 95 Pfam PF04355 SmpA / OmlA family
32 95 InterPro IPR007450 Lipoprotein SmpA/OmlA
21 112 Gene3D G3DSA:3.30.1450.10 -
21 112 InterPro IPR037873 BamE-like
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
1 21 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 19 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLT9
AlphaFold — — full sequence — Viewing
ColabFold KP13_05391
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.355